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STRUCTURE AND FUNCTION
The compound 5-HTP is a precursor to serotonin, a neurotransmitter involved in sending messages through the brain and nervous system. It supports a calm, relaxed mood and promotes feelings of well-being. Niacin (B-3), also known as nicotinic acid and nicotinamide, helps maintain a healthy nervous system. The major coenzyme forms of Vitamin B-6 are Pyridoxine (B-6), pyridoxal 5'-phosphate (PLP), and pyridoxamine (PMP). Vitamin B-6 supports brain and nervous system health. Valerian and its principle components have been extensively studied for well over 50 years. Lab data indicates that valerenic acid and acetylvalerenic acid in valerian can inhibit GABA transaminase, thereby prolonging the effects of GABA on sedation in the central nervous system. L-hydroxypinoresinol, another natural valerian alkaloid, has been found to possess a high affinity for the 5-HT1A receptor, which could also play a role in Valerian's beneficial effects.

CLINICAL EVIDENCE
In this study, 24 subjects received a one-time dose of 200 mg 5-hydroxytryptophan (5-HTP) or placebo in a double-blinded trial. The subjects receiving 5-HTP experienced a significantly calmer mood than the placebo group, supporting the use of 5-HTP for feelings of well-being. (Schruers et al, 2002) A total of 34 subjects were given either 200 mg of 5-HTP or placebo in a double-blinded clinical trial. The results showed a significant positive effect on feelings of calmness and well-being in the female subjects compared with placebo. (Maron et al, 2004)

SUMMARY
PhysioLogics 5-HTP provides a unique combination of several compounds that have effects on feelings of well-being, as well as brain and nervous system health.

Supplemental Facts:
PRODUCT BENEFITS: 5-HTP is a precursor to serotonin, a neurotransmitter involved in sending messages through the nervous system. This formula also includes B vitamins to promote nervous system health and the herb Valerian.

Ingredients:
Serving Size: 1 Capsule

Amount Per Serving
Niacin (as Niacinamide) ...5mg / 25% DV
Vitamin B-6 ...5mg / 250% DV
(as Pyridoxine Hydrochloride)
Magnesium (as Magnesium Oxide) ...25mg / 6% DV
5-HTP (from Griffonia Extract) ...100mg**
(Griffonia simplicifolia) (seed)
Valerian (Valeriana officinalis) (root) ...50mg**

**Daily Value not established.

Other Ingredients: Dicalcium Phosphate, Gelatin, Silica, Vegetable Magnesium Stearate.

FREE OF: artificial color, flavor or sweetener, preservatives, sugar, starch, milk, lactose, soy, gluten, wheat, yeast, fish, sodium.

Dosage:
Directions: For adults, take one (1) capsule twice daily as needed or before bedtime or follow the advice of your health care professional. As a reminder, discuss the supplements and medications you take with your health care providers.

WARNINGS:
WARNING:
Not for use by pregnant or lactating women. Avoid this product if you have heart problems or are taking antidepressants or weight-control drugs.

May Cause Drowsiness:
Do not drive a motor vehicle or operate heavy machinery while using this product. Consult your doctor before use if you have, or have had, ANY HEALTH CONDITION or if you are taking ANY MEDICATIONS OR REMEDIES, including OTC medications, or are planning any medical procedure. Discontinue use and consult your doctor if any adverse reactions occur, such as gastrointestinal discomfort, or headache.

NOT INTENDED FOR USE BY PERSONS UNDER THE AGE OF 18.