Acetyl L-Carnitine
250 mg

Promotes Memory and Cognitive Function

Dietary Supplement

60 Capsules

DOCTOR
RECOMMENDED

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For Health Care Professional Use Only

HOW PATIENTS MAY BENEFIT
Promotes nervous system health

PRODUCT DISCUSSION
PhysioLogics Acetyl-L-Carnitine (ALCAR) is similar in form to the amino acid L-Carnitine. It is synthesized in the brain, liver, and kidneys by the enzyme carnitine acetyltransferase and plays a role in the metabolism of food into energy. The acetyl group of Acetyl-L-Carnitine contributes to the production of the neurotransmitter acetylcholine, which is required for cognitive function.

STRUCTURE AND FUNCTION
Structurally similar to the neurotransmitter acetylcholine, ALCAR serves as the precursor to acetyl coenzyme A. Animal studies have shown that ALCAR can support neurons in the hippocampus and prefrontal cortex, facilitating learning and memory functioning. Additionally, ALCAR promotes healthy levels of normal shingomyelin accumulation to promote membrane fluidity and stability. ALCAR also plays a key role in cellular energy metabolism, transporting long-chain fatty acids across the mitochondrial membranes where they are utilized for ATP production, and shuttling small-chain and medium-chain fatty acids out of the mitochondria in order to maintain healthy coenzyme A levels. ALCAR helps maintain complex I and complex IV activity of the electron transport chain in aged mitochondria to further facilitate the mitochondrial energy supply. Finally, ALCAR may have antioxidant tendencies, supporting cells against peroxidation and promoting levels of reduced Glutathione and Coenzyme Q10. This property prevents lipid, protein, and DNA oxidative damage, which may further support brain function.

CLINICAL EVIDENCE
Thirty subjects completed a 3-month double-blind trial in which they received 1,000 mg of acetyl l-carnitine twice per day or an alternative preparation. At the end of the trial, the results demonstrated significant benefits in energy maintenance levels in those receiving acetyl lcarnitine compared to the alternative preparation. (Tomassini et al, 2004) Twenty subjects participated in a 4-week observational study in which they received 1,000 mg of acetyl l-carnitine twice per day. By week 3, a significant improvement in nervous system function was observed compared with baseline, based on questionnaire results. (Osio et al, 2006)

SUMMARY
PhysioLogics Acetyl-L-Carnitine helps promote cognitive function, memory, and nervous system health, and supports mitochondrial energy production.

PRODUCT DISCUSSION:
Acetyl L-Carnitine is similar in form to the amino acid L-Carnitine and plays a role in the metabolism of food into energy. The acetyl group of Acetyl LCarnitine contributes to the production of the neurotransmitter acetylcholine, which is required for cognitive function. Acetyl LCarnitine helps promote memory.

Ingredients:
Serving Size: 1 Capsule

Amount Per Serving
Acetyl L-Carnitine ...250mg**
(as Acetyl L-Carnitine Chloride)

**Daily Value not established.

Other Ingredients: Dicalcium Phosphate, Vegetable Cellulose, Cellulose (Plant Origin), Vegetable Magnesium Stearate, Silica. May contain Vegetable Glycerin.

FREE OF: yeast, wheat, milk or milk derivatives, lactose, sugar, preservatives, soy, artificial color, artificial flavor, sodium (less than 5 mg per serving).

Dosage:
Directions: For adults, take one (1) capsule four times daily, preferably between meals or follow the advice of your health care professional. As a reminder, discuss the supplements and medications you take with your health care providers.

WARNINGS:
KEEP OUT OF REACH OF CHILDREN.

STORE IN A DRY PLACE AND AVOID EXCESSIVE HEAT.

TAMPER RESISTANT: DO NOT USE IF SEAL UNDER CAP IS BROKEN OR MISSING.

WARNING: If you are pregnant, nursing or taking any medications, consult your doctor before use. Discontinue use and consult your doctor if any adverse reactions occur.