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The test uncovers potential genetic susceptibility to:
• Hypercholesteremia • Myocardial Infarction
• Atherosclerosis • Thromboses
• Obesity • Endothelial Dysfunction
• Hypertension • Stroke
• Coronary Artery Disease
Cholesterol Regulation and Atherosclerosis

ApoE (apoliprotein E)
CETP (cholesteryl ester transfer protein)
SELE (selectin E)
These genes affect how the body breaks down and clears fats and how cholesterol is
processed. They also affect lipid balance, plaque formation, and blood vessel integrity
and function.

Methylation
MTHFR (methylenetetrahydrofolate reductase)
Polymorphisms of this enzyme can disrupt the metabolism of homocysteine, resulting in
its accumulation as well as impaired methylation. The presence of these SNPs can increase
risk of cardiovascular disease, blood vessel damage, thromboses (blood clots), stroke, and
degenerative aging.

Hypertension
GNB3 (guanine nucleotide-binding protein)
AGT (angiotensin)
AGTR1 (angiotensin II receptor–1)
Polymorphisms of these genes are associated with blood vessel constriction, sodium
and water retention, obesity, and increased susceptibility to hypertension.

Coagulation
Factor 2 (prothrombin)
Factor 5 (Leiden)
These genetic variants can over-activate blood clotting processes, increasing the risk
of sudden cardiac events such as thromboses, heart attacks, and strokes.

Reduction-Oxidation Balance
CYBA*8 (cytochrome b-245-alpha)
This genetic variant mediates the balance between oxidative stress and antioxidant
defense in smooth muscle cells lining blood vessels.