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The test uncovers potential genetic susceptibility to:
• Asthma • Autoimmune Disorders
• Certain Cancers • Allergy
• Infectious Diseases • Bone Inflammation
• Arthritis • Inflammatory Bowel Disease
• Heart Disease • Osteopenia
• Helicobacter pylori infection (cause of ulcers)
Chronic Inflammation
• IL-1ß (interleukin-1beta)
This gene affects the duration and intensity of the acute inflammatory response. The
polymorphism leads to increased production of IL-1B, hypochlorhydria, increased
susceptibility to H. pylori infection, and gastritis and gastric cancer in H. pylori-infected
individuals.
TH-1 Cytokines (Viral Infection & Cancer)
• TNF-α (tumor necrosis factor-alpha)
Polymorphisms of this gene affect cell-mediated immunity, increasing production of the proinflammatory
cytokine TNF-alpha. This can promote or exacerbate chronic conditions such as
arthritis, osteoporosis, and asthma.
TH-2 Cytokines (Allergy, Asthma, and Atopy)
• IL-4 (interleukin-4) • IL-6 (interleukin-6)
• IL-10 (interleukin-10) • IL-13 (interleukin-13)
TH-2 cytokines promote humoral immunity, including the synthesis of IgE. They are generally
regarded as anti-inflammatory; however, excessive activity of some of these cytokines may
promote the development of allergic conditions such as atopy, asthma, and hypersensitivity.
Low levels may result in chronic inflammatory conditions characterized by a TH-1 response.
IL-6 has both pro- and anti-inflammatory properties; this cytokine drives the acute phase
response and can promote chronic inflammation and progression in autoimmune disease.

Specimen Requirements: